Stuart Tobet, Ph.D. (mPI, Senior Mentor TWIN 1 & 3)

Professor Department of Biomedical Sciences

School of Biomedical Engineering

Colorado State University

Stuart A. Tobet, Ph.D., CSU is Professor of Biomedical Sciences and Director of the CSU School of Biomedical Engineering. As Director of the CSU School of Biomedical Engineering that extends across 4 colleges and more than a dozen departments, his roles are to oversee a graduate training program and to promote interdisciplinary research at multiple levels in the university. He also serves on the University Graduate Education Council that provides him extensive input and understanding to a diverse universe of graduate student experiences. His laboratory studies how multiple signals affect migration and cell position that contribute to sex differences in structure or function in the developing nervous system and more recently in the gastrointestinal tract. Live video microscopy studies in his laboratory provided the first direct evidence of sex differences and hormone influences on neuronal migration.

Most recently his lab established an ex vivo intestinal slice model that allows the study of neuroimmune and microbiome mechanisms in intestinal slices maintained ex vivo for several days. This recent work that for mouse models includes the enteric nervous system makes it possible to address peripheral issues downstream of autonomic dysregulation.

Read more about Dr. Tobet: http://csu-cvmbs.colostate.edu/academics/bms/Pages/stuart-tobet.aspx

Publications

Tobet SA, Zahniser DJ and Baum MJ: Differentiation in male ferrets of a sexually dimorphic nucleus of the preoptic/anterior hypothalamic area requires prenatal estrogen. Neuroendocrinology 44:229-308 (1986). PMID: 3808217

​ Henderson RG, Brown AE, and Tobet SA: Sex differences in cell migration in the preoptic area/anterior hypothalamus of mice. J. Neurobiol., 41:252-266 (1999). PMID: 10512982

Bless EP, Walker HJ, Yu KW, Knoll JG, Moenter SM, Schwarting GA, Tobet SA: Live view of gonadotropin-releasing hormone containing neuron migration. Endocrinology, 146:463-468 (2005). PMID: 15486219

Davis AM, Seney ML, Stallings NR, Zhao L, Parker KL, Tobet SA: Loss of Steroidogenic Factor 1 alters cellular topography in the mouse ventromedial nucleus of the hypothalamus. J. Neurobiol., 60:424-436 (2004). PMID: 15307147

Schwerdtfeger LA, Ryan EP, Tobet SA: An Organotypic Slice Model For Ex Vivo Study of Neural, Immune and Microbial Interactions of Mouse Intestine. Am J Physiol Gastrointest Liver Physiol: 310(4):G240-8 (2016). PMID: 26680736

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