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Understanding the nature of these differences and impact on treatment is critical for realizing precision medicine. We believe there are shared causal pathways that explain sex differences that cross organs and systems throughout the brain and body. This is not surprising since every cell has a sex, and gonadal hormones (that differ by sex) have impact throughout the body. However, medicine has been built primarily on studies of male animals and within departmental silos. Thus, therapies are not targeted to multiple organs nor incorporate sex differences. 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Understanding the nature of these differences and impact on treatment is critical for realizing precision medicine. We believe there are shared causal pathways that explain sex differences that cross organs and systems throughout the brain and body. This is not surprising since every cell has a sex, and gonadal hormones (that differ by sex) have impact throughout the body. However, medicine has been built primarily on studies of male animals and within departmental silos. Thus, therapies are not targeted to multiple organs nor incorporate sex differences. The Innovation Center on SeX Differences in Medicine (ICON-✘) is going to change that. 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The event brought together the ecosystem including 250+ experts, ecosystem builders, investors, corporates, researchers, entrepreneurs, and innovators to co-create new solutions and to launch initiatives for better health for all. Keynote : keynote on the Impact of Sex on Risk & Therapeutics for Chronic Disease. https://www.tech4eva.ch/event/tech4eva-opening-ceremony-2022 https://www.icon.mgh.harvard.edu/advocacy daily 0.75 2024-03-15 https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1576314410938-F4Y814BLGI2QIXL673G5/advocacy_banner.jpg Advocacy https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1576640560827-D5FXQ8VJ9TAOC9C08COV/dominik-lange-VUOiQW4OeLI-unsplash.jpg Advocacy https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/b258d65d-f746-4f80-8abb-2ae4b54a877e/Today+Show+interview_Linkedin+option+.png Advocacy - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1576640585494-HHFK55AV3WIZKOUG0KRC/image-asset.jpeg Advocacy https://www.icon.mgh.harvard.edu/research-overview daily 0.75 2021-12-08 https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1638949625753-5JKDC2XQ111NDU0ITO61/Brain_Heart+%281%29.png Research Overview https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/512f03f6-f964-4944-ba9b-982b049dde80/Hypothalamus_method_sex+differencs_Hypo-fig4_VERY+COOL.png Research Overview - Project 1: Sex & Prenatal Stress, Immunity, Depression, & CVD Risk https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/7865b8e8-e3e1-4f04-8dbb-857a1f303ac0/unnamed+%282%29.png Research Overview - Project 2: Sex & Stress, Autonomic & Regulation, Depression & Neuromodulation https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/02ad324f-c9de-4979-b199-35cc2f8dbd01/project3.jpg Research Overview - Project 3: Sex & Prenatal Stress, Hypothalamus, ANS & Cardiovascular function in Rodent Models https://www.icon.mgh.harvard.edu/score2020 daily 0.75 2024-02-21 https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/ff7e3bb9-e3bf-4162-909a-56f06d9ec2d6/Banner_2024+with+logos+cropped+reduced.png SCORE 2020 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/ce553ca3-88a5-401d-af34-cf7871d93563/SCORE+Admin+Tree+%285%29.png SCORE 2020 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1630464999833-KIHCSEIAO8DYZVO9QQSN/pexels-pixabay-327178.jpg SCORE 2020 - support our research Important discoveries are being made every day. Consider supporting us to make greater strides in our research through making a donation. https://www.icon.mgh.harvard.edu/score-project1 daily 0.75 2021-12-10 https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1636842861206-JVKPWH9UG8MC9WI137AO/Untitled.jpg Project 1 https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1c207413-3770-4fa6-bbf5-6081ca309d8b/slideshow1.png Project 1 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/975ba301-4ba8-4572-81ed-7c4bf35044cb/banner.jpg Project 1 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/06a7170f-670a-400e-9b6a-6a18a16a1f7a/unnamed+%281%29.png Project 1 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.icon.mgh.harvard.edu/score-cec daily 0.75 2025-03-04 https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1630474031095-4PTSKEQNSB06AOG4URKD/pexels-olenka-sergienko-3646172.jpg Career Education Core https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1635221358328-52X9DID38WRP9SPKCKUL/andrea-edlow.jpeg Career Education Core https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1660597825582-2CS1RJ47C0GTSW5R95RR/Evan+Bordt.png Career Education Core https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/24d4ada6-105a-4a22-bb73-511282772602/SeligowskiHeadshot198Sep317.jpg Career Education Core https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/7cce7f26-d59c-4384-9b8f-03a0205506e8/Screen+Shot+2023-01-13+at+4.51.52+PM.png Career Education Core - Our CSU & University of Arizona CEC Scholars Also part of the CEC, as CEC Scholars, Julietta Sheng, PhD (CSU), Emily Castellanos, PhD Student (CSU Diversity Supplement recipient) and Mina Roueinfar, PhD Student, are working with Dr Stuart Tobet within the Department of Biomedical Sciences in Colorado. Lakshmi Madhavpeddi, PhD, Sebastiao Donato Silva Junior, PhD and Monique Martinez, PhD Student (AZ Diversity Supplement Recipient) work with Dr Taben Hale at the University of Arizona, College of Medicine - Phoenix Their research and pilot-projects strengthen our U54 SCORE. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/5a2753a1-1a4f-43c7-b7d1-5ff0f61e4b4a/Emily+and+Julietta+ENDO.jpeg Career Education Core - ENDO 2024 Boston Emily Castellanos (CSU) presenting her work on microglia in the brainstem. Dr Julietta Sheng (CSU) has also presented her work on animal models at the ENDO June 2024 conference https://www.icon.mgh.harvard.edu/score-project2 daily 0.75 2021-12-16 https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1637738946434-OQ8PFPK95FO54V1Y2TOA/unnamed.png Project 2 https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/b943ee37-8f57-4eb2-9588-bf40009d6237/P3.png Project 2 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/f5b32daf-b3c2-42ed-9d95-ae43dce88750/unnamed+%283%29.png Project 2 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/672c57ba-0543-4c17-8752-f0355c17ed08/specific+aims+image.png Project 2 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.icon.mgh.harvard.edu/score-project3 daily 0.75 2021-12-16 https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1636842082895-3RD2JTOMHVEX1NU4Y53E/CRH_CeA_20x+P3.jpg Project 3 https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/4af2b41d-71f0-4812-b4d0-88f391301141/i8m4+dex+avp+tdt+avp+488+9.27.21+pvn+40x_2021-09-27T13-51-32.685+%282%29.jpg Project 3 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/e0527cbd-a18c-42f2-af58-9921152179e8/p3_aim1.png Project 3 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/5b74b004-60ad-4d58-bcdd-4d1df294f03b/p3_aim3.png Project 3 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.icon.mgh.harvard.edu/score-rsc daily 0.75 2021-12-02 https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1636667330261-20L635WH33UFK2Q7C3D9/rsc+banner.png Resource Support Core https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/3bfc2bd8-d8f2-4143-bb9e-67e5dcf107f8/image002.png Resource Support Core - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/40de21aa-54f4-4d4c-bd7e-97b31e02f190/rr_ppHRV.png Resource Support Core - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/dc90f11f-25b9-4243-9a2c-6c728676561d/7T_fMRI_brainstem.jpg Resource Support Core - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.icon.mgh.harvard.edu/leadership-admin-core daily 0.75 2021-11-24 https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1636671658274-DXM3THGTLNHHG5YBAF3D/rsc.jpg Leadership Admin Core https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/b6b59693-d17d-4763-8966-e099c0d77b70/SCORE+Admin+Tree+%285%29.png Leadership Admin Core - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1633502159877-PFGU96LBILAIL468VA41/Screen+Shot+2021-10-05+at+11.29.54+PM.png Leadership Admin Core - Make it stand out View tribute https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1636680531865-5J4KEIBINXIR67FMVWH4/1.+orwh-nimh-logo.png Leadership Admin Core https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1636844281034-GNOZ40FSJHJ2BOER6HOP/2.+SCORE_U54+logo.png Leadership Admin Core https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1636844105835-7BDX50I0RRZ5VNPTHX7J/3.+mghri+mass+general.png Leadership Admin Core https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1636844448829-IW7QHB49S4U7U3SB2DUC/4.+csu.png Leadership Admin Core https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1636680583324-3ENZRKCHC2KYGAV35DPL/5.+university+of+az.png Leadership Admin Core https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1636680532980-OARH713VG1W9KQO4NO8Y/6.+hsph.jpg Leadership Admin Core https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1636680533463-B06AJD35V9IARXSPAJU9/7.+brown-logo.png Leadership Admin Core https://www.icon.mgh.harvard.edu/bob-handa-tribute daily 0.75 2021-10-28 https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1635396451788-S4ED9BGR9O9OA17XTHAI/handa+headshot.jpg Bob Handa Tribute https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1635396505204-D9NCYBN7JSJ0J7NO9DA5/hand+headshot2.jpg Bob Handa Tribute - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.icon.mgh.harvard.edu/score-publications daily 0.75 2021-11-25 https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1635394638011-IVLICGXDNV3FMQXO9T7X/books-5937716_1920-edit.jpg Publications https://www.icon.mgh.harvard.edu/diseases daily 0.75 2025-03-12 https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1678308576675-IPLIQFY7T9LQFTKXRPFE/unsplash-image-vXymirxr5ac.jpg Diseases - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1675409096823-MDNMPV712OCFGX3KI76M/unsplash-image-zBsdRTHIIm4.jpg Diseases - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1678308487319-GWA1VWI311Q1F0XPWL11/unsplash-image-i1iqQRLULlg.jpg Diseases - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1675409138951-4B9TFY6PWQPINEI9G5J1/unsplash-image-nsQj12P4uiI.jpg Diseases - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/f0fdf0f8-2e92-4dd0-a06e-ebdad42ffed0/lookingmatter_brainfiber.jpeg Diseases https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1678308653694-8BH7M42ACENZLA3LL5JT/unsplash-image-yhDnHJybJms.jpg Diseases - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1675409603072-YUNORFN2AEALDNMN4QAE/unsplash-image-lTlB51-XGP4.jpg Diseases - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1678308536817-NAVSEDSAB971G7FSECC2/unsplash-image-ZJaK9jQXeDA.jpg Diseases - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1675409792751-7AU2VJ7VCS5OKNFX6X2J/unsplash-image-sxQz2VfoFBE.jpg Diseases - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1675409807947-OR1795VT5A0PE1T4KZNR/unsplash-image-rXrMy7mXUEs.jpg Diseases - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1675409832129-02I0811EXDLAE96TG1F4/unsplash-image-son4VHt4Ld0.jpg Diseases - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1678313232783-WHW71Q767CK69FP1HYA3/unsplash-image-78hTqvjYMS4.jpg Diseases - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.icon.mgh.harvard.edu/diseases-of-interest daily 0.75 2023-03-17 https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1679094833410-AN2M4DNQ2DNEE93VZNRF/Research%2BBanner.jfif Diseases of Interest https://www.icon.mgh.harvard.edu/twin daily 0.75 2025-04-15 https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1708447435569-YXTSNKWID5RYJX86EF1U/pexels-kindel-media-8325710+%281%29.jpg Translational Workforce Innovation Network (TWIN) https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/ec87d69b-ec01-40d6-9747-1866b401d4f0/TWIN+visual_4.4.24+new+%28D%29.png Translational Workforce Innovation Network (TWIN) - The TWIN Model The Translational Workforce Innovation Network (TWIN) represents a strategic enhancement to the existing U54 SCORE program, leveraging the expertise of the Mass General Hospital Research Institute Longfellow Project to facilitate a seamless transition from basic research to clinical applications and commercialization. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1708459353431-1A957MV7Y0LB61PP7L7W/BIRCWH+photo.jpeg Translational Workforce Innovation Network (TWIN) https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1708446914493-QHQZUDGTA8NVFGUCBCG5/bc2de4ad-e53d-494a-9172-355b3c9418f9.jpg Translational Workforce Innovation Network (TWIN) https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1708444031313-44EJP7ZUYWDTVZWQKMKU/ICON+X+team.JPG Translational Workforce Innovation Network (TWIN) https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1709070951087-NIBD0P4ZVEA47CGM6PN3/Taben_Hale_lab_2023_credit_deanna_sanchez_P1025282.JPG Translational Workforce Innovation Network (TWIN) https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1708444021911-HRABRCOSVJYVSUQCKLDS/IMG_9696.JPG Translational Workforce Innovation Network (TWIN) https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1708443775865-7JMBRD0KRMVYBOTRKNAZ/Colorado-State-University-Welcome-cropped.jpg Translational Workforce Innovation Network (TWIN) https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1709070971375-WXQRLNMYW2RD4PDEBKWT/FullSizeRender.JPEG Translational Workforce Innovation Network (TWIN) https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1708459368491-RV1YGHRGESJZ4CG3BSZV/RAchel%2C+jules+and+taben+.jpeg Translational Workforce Innovation Network (TWIN) https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/87d3a0c3-9102-4c4a-888b-de23c2553236/Screenshot+2024-02-20+at+10.09.43+AM.png Translational Workforce Innovation Network (TWIN) https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/5251f86c-85af-468d-9f42-50f4fb233f5d/RESEARCH-AdobeStock_142270989.jpg Translational Workforce Innovation Network (TWIN) https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/d317ae66-9d51-47c1-becb-b8ccb6d05e16/Screenshot+2024-02-20+at+10.12.21+AM.png Translational Workforce Innovation Network (TWIN) https://www.icon.mgh.harvard.edu/press-quote-impact daily 0.75 2025-05-08 https://www.icon.mgh.harvard.edu/our-impact-impact daily 0.75 2025-05-08 https://www.icon.mgh.harvard.edu/get-involved-impact daily 0.75 2025-05-08 https://www.icon.mgh.harvard.edu/introduction-impact daily 0.75 2025-05-08 https://www.icon.mgh.harvard.edu/banner-impact daily 0.75 2025-05-08 https://images.squarespace-cdn.com/content/v1/59dbc7c2cf81e0c47e15482d/1509981485774-SEFF87258WRO7RY3PZKE/_50A4240.jpg Banner https://www.icon.mgh.harvard.edu/advocacy-copy daily 0.75 2025-11-25 https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1576314410938-F4Y814BLGI2QIXL673G5/advocacy_banner.jpg Advocacy (Copy) https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1576640560827-D5FXQ8VJ9TAOC9C08COV/dominik-lange-VUOiQW4OeLI-unsplash.jpg Advocacy (Copy) https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/b258d65d-f746-4f80-8abb-2ae4b54a877e/Today+Show+interview_Linkedin+option+.png Advocacy (Copy) - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5da243c63b1ad128da8ee81b/1576640585494-HHFK55AV3WIZKOUG0KRC/image-asset.jpeg Advocacy (Copy)