Examples of Our Foundational SCORE Work

  1. Goldstein JM, Hale T, Foster SL, Tobet SA, Handa RJ. Sex differences in major depression and comorbidity of cardiometabolic disorders: impact of prenatal stress and immune exposures. Neuropsychopharmacology. 2019 Jan;44(1):59-70. doi: 10.1038/s41386-018-0146-1. PMID: 30030541
  2. Goldstein JM, Holsen L, Huang G, Hammond BD, James-Todd T, Cherkerzian S, Hale TM, Handa RJ. Prenatal stress-immune programming of sex differences in comorbidity of depression and obesity/metabolic syndrome. Dialogues Clin Neurosci. 2016 Dec;18(4):425-436. doi: 10.31887/DCNS.2016.18.4/jgoldstein. PMID: 28179814
  3. Handa RJ, Weiser MJ. Gonadal steroid hormones and the hypothalamo-pituitary-adrenal axis. Front Neuroendocrinol. 2014 Apr;35(2):197-220. doi: 10.1016/j.yfrne.2013.11.001. PMID: 24246855
  4. Tobet SA, Handa RJ, Goldstein JM. Sex-dependent pathophysiology as predictors of comorbidity of major depressive disorder and cardiovascular disease. Pflugers Arch. 2013 May;465(5):585-94. doi: 10.1007/s00424-013-1248-6. PMID: 23503726
  5. Majdic G, Tobet S. Cooperation of sex chromosomal genes and endocrine influences for hypothalamic sexual differentiation. Front Neuroendocrinol. 2011 Apr;32(2):137-45. doi: 10.1016/j.yfrne.2011.02.009. Epub 2011 Feb 19. PMID: 21338619
  6. Weiser MJ, Foradori CD, Handa RJ. Estrogen receptor beta in the brain: from form to function. Brain Res Rev. 2008 Mar;57(2):309-20. doi: 10.1016/j.brainresrev.2007.05.013. PMID: 17662459
  7. Lund TD, Rovis T, Chung WC, Handa RJ. Novel actions of estrogen receptor-beta on anxiety-related behaviors. Endocrinology. 2005 Feb;146(2):797-807. doi: 10.1210/en.2004-1158. PMID: 15514081
  8. Tobet SA. Genes controlling hypothalamic development and sexual differentiation. Eur J Neurosci. 2002 Aug;16(3):373-6. doi: 10.1046/j.1460-9568.2002.02105.x.PMID: 12193176
  9. Byne W, Tobet S, Mattiace LA, Lasco MS, Kemether E, Edgar MA, Morgello S, Buchsbaum MS, Jones LB. The interstitial nuclei of the human anterior hypothalamus: an investigation of variation with sex, sexual orientation, and HIV status. Horm Behav. 2001 Sep;40(2):86-92. doi: 10.1006/hbeh.2001.1680. PMID: 11534967
  10. SA Tobet, TO Fox. Sex differences in neuronal morphology influenced hormonally throughout life. Book: Sexual differentiation. 1992. Pages: 41-83. Publisher. Springer, Boston, MA


Project 1 Publications

  1. Goldstein, JM, Jerram, M, Abbs, B, Whitfield-Gabrieli, S, Makris, N. Sex differences in stress response circuitry activation dependent on female hormonal cycle. Journal of Neuroscience 2010, 30 (2): 431-438. PMID: 20071507. PMCID: PMC2827936. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827936/
  2. Jacobs EG, Holsen LM, Lancaster K, Makris N, Whitfield-Gabrieli S, Remington A, Weiss B, Buka S, Klibanski A, Goldstein JM. 17β-Estradiol Differentially Regulates Stress Circuitry Activity in Healthy and Depressed Women. Neuropsychopharmacology. 2014 Aug 12. doi: 10.1038/npp.2014.203. [Epub ahead of print] PMID: 25113601 https://www.nature.com/articles/npp2014203
  3. Mareckova K, Holsen LM, Admon R, Makris N, Seidman L, Buka S, Whitfield-Gabrieli S, Goldstein JM. Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses. Hum Brain Mapp. 2016 June 1. doi: 10.1002/hb.23271. PMID: 27246897 PMCID: PMC5053909 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053909/
  4. Goldstein, JM, Hale, T, Foster, SL, Tobet, SA, Handa, RJ. Sex Differences in Major Depression and Comorbidity of Cardiometabolic Disorders: Impact of Prenatal Stress and Immune Exposures, Neuropsychopharmacology, Special issue on Sex Differences (T. Bale, Ed), 2018 July 7: 1 PMID: 30030541. https://www.nature.com/articles/s41386-018-0146-1
  5. Gilman SE, Cherkerzian S, Buka SL, Hahn J, Hornig M, Goldstein JM. Prenatal immune programming of the sex-dependent risk for major depression. Transl Psychiatry. 2016 May 31;6(5):e822. PMID: 27244231 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545649/pdf/tp201691a.pdf
  6. Goldstein JM, Cohen JE, Mareckova K, Holsen L, Whitfield-Gabrieli S, Gilman SE, Buka SL, Hornig, M. Impact of prenatal cytokine exposure on sex differences in brain circuitry regulating stress in offspring 45 years later. 2021; Proceedings of the National Academy of Sciences. Proc Natl Acad Sci USA April 13, 2021 118 (15) e2014464118; https://doi.org/10.1073/pnas.2014464118
  7. Blokland, G.A.M., Grove, J., Chen, C., Cotsapas, C., Tobet, S., Handa, R., Petryshen, T.L., Smoller, J.W., Goldstein, J.M. Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders, Biological Psychiatry, 2021, https://www.biologicalpsychiatryjournal.com/article/S0006-3223(21)01139-2/fulltext


Project 2 Publications

  1. Mareckova K, Holsen L, Admon R, Whitfield-Gabrieli S, Seidman LJ, Buka SL, Klibanski A, Goldstein JM. Neural - hormonal responses to negative affective stimuli: Impact of dysphoric mood and sex. J Affect Disord. 2017 Nov;222:88-97. doi: 10.1016/j.jad.2017.06.050. Epub 2017 Jun 28. PubMed PMID: 28688266; PubMed Central PMCID: PMC5560420.
  2. Garcia RG, Mareckova K, Holsen LM, Cohen JE, Whitfield-Gabrieli S, Napadow V, Barbieri R, Goldstein JM. Impact of sex and depressed mood on the central regulation of cardiac autonomic function. Neuropsychopharmacology. 2020 Jul;45(8):1280-1288. doi: 10.1038/s41386-020-0651-x. Epub 2020 Mar 9. PubMed PMID: 32152473; PubMed Central PMCID: PMC7298013.
  3. Garcia RG, Lin RL, Lee J, Kim J, Barbieri R, Sclocco R, Wasan AD, Edwards RR, Rosen BR, Hadjikhani N, Napadow V. Modulation of brainstem activity and connectivity by respiratory-gated auricular vagal afferent nerve stimulation in migraine patients. Pain. 2017 Aug;158(8):1461-1472. doi: 10.1097/j.pain.0000000000000930. PubMed PMID: 28541256; PubMed Central PMCID: PMC5517046.
  4. Sclocco R, Garcia RG, Kettner NW, Isenburg K, Fisher HP, Hubbard CS, Ay I, Polimeni JR, Goldstein J, Makris N, Toschi N, Barbieri R, Napadow V. The influence of respiration on brainstem and cardiovagal response to auricular vagus nerve stimulation: A multimodal ultrahigh-field (7T) fMRI study. Brain Stimul. 2019 Jul - Aug;12(4):911-921. doi: 10.1016/j.brs.2019.02.003. Epub 2019 Feb 10. PubMed PMID: 30803865; PubMed Central PMCID: PMC6592731.
  5. Staley R, Garcia RG, Stowell J, Sclocco R, Fisher H, Napadow V, Goldstein JM, Barbieri R. Modulatory Effects of Respiratory-Gated Auricular Vagal Nerve Stimulation on Cardiovagal Activity in Hypertension. Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:2581-2584. doi: 10.1109/EMBC44109.2020.9175768. PubMed PMID: 33018534.
  6. Sclocco R, Garcia RG, Kettner NW, Fisher HP, Isenburg K, Makarovsky M, Stowell JA, Goldstein J, Barbieri R, Napadow V. Stimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation. Brain Stimul. 2020 Jul - Aug;13(4):970-978. doi: 10.1016/j.brs.2020.03.011. Epub 2020 Mar 27. PubMed PMID: 32380448; PubMed Central PMCID: PMC7931850.
  7. Garcia RG, Cohen JE, Stanford AD, Gabriel A, Stowell J, Aizley H, Barbieri R, Gitlin D, Napadow V, Goldstein JM. Respiratory-gated auricular vagal afferent nerve stimulation (RAVANS) modulates brain response to stress in major depression. J Psychiatr Res. 2021 Oct;142:188-197. doi: 10.1016/j.jpsychires.2021.07.048. Epub 2021 Aug 2. PubMed PMID: 34365067; PubMed Central PMCID: PMC8429271.


Project 3 Publications

  1. Sheng JA, Bales NJ, Myers SA, Bautista AI, Roueinfar M, Hale TM, Handa RJ. The hypothalamic-pituitary-adrenal axis: development, programming actions of hormones, and maternal-fetal interactions. Frontiers in Behavioral Neuroscience. (2021) 14:601939.
  2. Goldstein JM, Holsen L, Huang G, et al. Prenatal stress-immune programming of sex differences in comorbidity of depression and obesity/metabolic syndrome. Dialogues Clin Neurosci. 2016;18(4):425-436. doi:10.31887/DCNS.2016.18.4/jgoldstein
  3. Goldstein JM, Hale T, Foster SL, Tobet SA, Handa RJ. Sex differences in major depression and comorbidity of cardiometabolic disorders: impact of prenatal stress and immune exposures. Neuropsychopharmacology. 2019;44(1):59-70. doi:10.1038/s41386-018-0146-1
  4. Frahm KA, Handa RJ, Tobet SA. Embryonic Exposure to Dexamethasone Affects Nonneuronal Cells in the Adult Paraventricular Nucleus of the Hypothalamus. J Endocr Soc. 2017;2(2):140-153. Published 2017 Dec 28. doi:10.1210/js.2017-00439
  5. Hiroi R, Carbone DL, Zuloaga DG, Bimonte-Nelson HA, Handa RJ. Sex-dependent programming effects of prenatal glucocorticoid treatment on the developing serotonin system and stress-related behaviors in adulthood. Neuroscience. 2016;320:43-56. doi:10.1016/j.neuroscience.2016.01.055
  6. Carbone DL, Zuloaga DG, Lacagnina AF, McGivern RF, Handa RJ. Exposure to dexamethasone during late gestation causes female-specific decreases in core body temperature and prepro-thyrotropin-releasing hormone expression in the paraventricular nucleus of the hypothalamus in rats. Physiol Behav. 2012;108:6-12. doi:10.1016/j.physbeh.2012.07.010
  7. Carbone DL, Zuloaga DG, Lacagnina AF, Handa RJ. Prepro-thyrotropin releasing hormone expressing neurons in the juxtaparaventricular region of the lateral hypothalamus are activated by leptin and altered by prenatal glucocorticoid exposure. Brain Res. 2012;1477:19-26. doi:10.1016/j.brainres.2012.08.020