Jordan Smoller, M.D., Sc.D.
Professor of Psychiatry, Harvard Medical School
Professor, Department of Epidemiology, Harvard School of Public Health
Director, Psychiatric and Neurodevelopmental Genetics Unit,
Massachusetts General Hospital’s Center for Human Genetics Research
Dr. Jordan Smoller is a psychiatrist, epidemiologist, and geneticist whose research focus has been 1) understanding the genetic and environmental determinants of psychiatric disorders across the lifespan; 2) integrating genomics and neuroscience to unravel how genes affect brain structure and function; and 3) using “big data”, including electronic health records and genomics, to advance precision medicine.
Dr. Smoller earned his undergraduate degree at Harvard University and his medical degree at Harvard Medical School. After completing residency training in psychiatry at McLean Hospital, he received masters and doctoral degrees in epidemiology at the Harvard School of Public Health.
Dr. Smoller is the Massachusetts General Hospital (MGH) Trustees Endowed Chair in Psychiatric Neuroscience, Professor of Psychiatry at Harvard Medical School and Professor in the Department of Epidemiology at the Harvard School of Public Health in Boston. He is Associate Chief for Research in the MGH Department of Psychiatry and Director of both the Psychiatric and Neurodevelopmental Genetics Unit and the Precision Medicine Research Unit in the MGH Center for Genomic Medicine. Dr. Smoller is a Tepper Family MGH Research Scholar and also serves as Director of the Omics Unit of the MGH Division of Clinical Research and co-Director of the Partners HealthCare Biobank at MGH. He is an Associate Member of the Broad Institute and Vice President of the International Society of Psychiatric Genetics. He is a PI in the Electronic Medical Records and Genomics (eMERGE) network and contact PI of the New England Precision Medicine Consortium as part of the NIH Precision Medicine Initiative’s All of Us Research Program. He is an author of more than 300 scientific publications and is also the author of The Other Side of Normal (HarperCollins/William Morrow, 2012).
Publications
Smoller JW, Andreassen OA, Edenberg HJ, Faraone SV, Glatt SJ, and Kendler, KS. Psychiatric genetics and the structure of psychopathology. Mol Psychiatry. 2018 Jan 9. doi: 10.1038/s41380-017-0010-4. [Epub ahead of print] PMID: 29317742
Barak-Corren Y, Castro VM, Javitt S, Hoffnagle AG, Dai Y, Perlis RH, Nock MK, Smoller JW, Reis BY. Predicting Suicidal Behavior From Longitudinal Electronic Health Records. Am J Psychiatry, 2017 Feb 1;174(2):154-162. Epub 2016 Sep 9. PMID: 27609239 Corresponding author
Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet.2013 Apr 20;381(9875):1371-9. PMID: 23453885
Lee PH, Baker JT, Holmes AJ, Jahanshad N, Ge T, Jung JY, Cruz Y, Manoach DS, Hibar DP, Faskowitz J, McMahon KL, de Zubicaray GI, Martin NH, Wright MJ, Öngür D, Buckner R, Roffman J, Thompson PM, Smoller JW. Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia. Mol Psychiatry. 2016 Oct 11. PMID: 27725656
Choi KW, Chen C-Y, Stein MB, Klimentidis YC, Wang M-J, Koenen KC, Smoller JW. Bidirectional Relationships Between Physical Activity and Depression Among Adults: A 2-sample Mendelian Randomization Study. JAMA Psychiatry, in press. 2019 Jan 23. doi: 10.1001/jamapsychiatry.2018.4175. [Epub ahead of print] PMID: 30673066
Ge T, Chen CY, Neale BM, Sabuncu MR, Smoller JW. Phenome-wide heritability analysis of the UK Biobank. PLoS Genet. 2017 Apr 7;13(4):e1006711. doi: 10.1371/journal.pgen.1006711. PMID: 28388634